Endocrine Abstracts

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. Prior to this study, we confirmed that Calbindin-D9k (CaBP-9k) was responsible for regulation of the distribution of free calcium in the cytoplasm. We also confirmed that insulin-secreting β cells express CaBP-9k, and assumed that CaBP-9k play a role in β c...

Calcium ion is important for physiological functions in all tissues and organs, and is essential for many vital functions. Calcium in lumen is absorbed to cytosol, and Calbindin-D9k binds calcium. It can remove calcium to extracellular through PMCA1 and NCX1. However, in the rat esophagus, the calcium related gene regulations and localizations were not well documented. We evaluated calcium related genes including Calbindin-D9k, PMCA1, and NCX1. Immature rats were daily treated...